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Scientific Research & Evidence


Schelee, Windried and others, “Mapping Cortical Hubs in Tinnitus”, in BMC Biology 2009 (http://bmcbiol.biomedcentral.com/articles/10.1186/1741-7007-7-80)

Sedley, William and others, “Intracranial Mapping of Cortical Tinnitus System Using Residual Inhibition”, in Current Biology, Volume 25, Issue 9, p. 1209-124, May 2015 (http://www.cell.com/current-biology/abstract/S0960-9822(15)00278-X)

Luscher, Christian, “The Synapse: Center Stage for Many Brain Diseases”, in The Journal of Physiology, February 2009, p. 727-729 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669966/)

Mahoney, Colin J. and others, “Structural Neuroanatomy of Tinnitus and Hypercusis in Semantic Dementia”, in Journal of Neurology, Neurosurgery and Psychiatry, p. 1274-1278, November 2011 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188784/)

David O. Kennedy, “B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review”, in Nutrients, February 2016 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772032/)

Marnett, Lawrence J., “Free Radical Mechanism of Neurotoxicity”, in Chemical Research in Toxicology, volume 10, Issue 5, May 1997 (http://pubs.acs.org/doi/pdf/10.1021/tx970493u)

Weisz, Moratti and others, "Tinnitus Perception and Distress is - ...", in University of Konstanz (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160568/)

Joy Victory, "10 common myths about tinnitus", in Healthy Hearing 2020 (https://www.healthyhearing.com/report/52702-Top-10-myths-about-tinnitus)

NIDCD, "Tinnitus: Is this what happens when the brain's gatekeeper breaks down?", in NIDCD 2011 (https://www.audiologyonline.com/releases/tinnitus-this-what-happens-when-2320)





REFERENCES:

Hibiscus (Hibiscus sabdariffa)
Salem MA, Ezzat SM, Ahmed KA, Alseekh S, Fernie AR, Essam RM. A Comparative Study of the Antihypertensive and Cardioprotective Potentials of Hot and Cold Aqueous Extracts of Hibiscus sabdariffa L. in Relation to Their Metabolic Profiles. Front Pharmacol. 2022 Feb 23;13:840478. doi: 10.3389/fphar.2022.840478. PMID: 35281911; PMCID: PMC8905494.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905494/

Hawthorne Berry (Crataegus oxyacantha)
"Caffeic acid “Caffeic acid has been identified in plants used for medicinal purposes, includingDavalla mariesii Moore (Davalliaceae), a fern used in Korean folk medicine for the treatment of the common cold, neuralgia and stomach cancer and in China as a traditional medicine for treatment of lumbago, rheumatism, toothache and tinnitus (Cui et al., 1990); the roots of Carissa spinarum L. (Apocyaceae), a thorny, evergreen shrub ... including caffeic acid, in the medicinal plant Crataegus oxyacantha”
https://www.ncbi.nlm.nih.gov/books/NBK513593/

Olive Extract
"Olive: MedlinePlus Supplements, U.S. National Library of Medicine, “applied to the skin (used topically) for earwax, ringing ears (tinnitus), pain in the ears,”
https://medlineplus.gov/druginfo/natural/233.html

Niacin (B3) (Nicotinic acid)
Tinnitus: Facts, Theories, and Treatments “Atkinson (1944a) found that about 50 percent of his (selected) patients reported relatively long-term relief from their tinnitus while under chronic maintenance dosages of nicotinic acid”
https://www.ncbi.nlm.nih.gov/books/NBK217858/

Vitamin B12
Diagnostic Approach to Tinnitus RICHARD W. CRUMMER, M.D., and GHINWA A. HASSAN, M.D. State University of New York–Downstate, Brooklyn, New York “Various metabolic abnormalities may be associated with tinnitus. These abnormalities include hypothyroidism, hyperthyroidism, hyperlipidemia, anemia, and vitamin B12 or zinc deficiency”
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.730.8719&rep;=rep1&type;=pdf

Vitamin B6
Alternative medications and other treatments for tinnitus: facts from fiction Michael D. Seidman, MD a,*, Seilesh Babu, MD Department of Otolaryngology–Head and Neck Surgery, Henry Ford Health System "Supplemental B6 is commonly used as a treatment for nausea, morningsickness, depression, and tinnitus."
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.543.8889&rep;=rep1&type;=pdf

Buchu leaves (Agathosma betulina)
"Pharmacognostical Profile of Selected Medicinal Plants" , in Handbook of African Medicinal Plants au. Maurice M. Iwu (Boca Raton: CRC Press, 04 Feb 2014 ), accessed 08 Aug 2023 , Routledge Handbooks Online.
https://www.routledgehandbooks.com/doi/10.1201/b16292-4#sec3_9

Green Tea
Ohishi T, Goto S, Monira P, Isemura M, Nakamura Y. Anti-inflammatory Action of Green Tea. Antiinflamm Antiallergy Agents Med Chem. 2016;15(2):74-90. doi: 10.2174/1871523015666160915154443. PMID: 27634207.
https://pubmed.ncbi.nlm.nih.gov/27634207/

Uva ursi (Arctostaphylos uva-ursi)
LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Uva Ursi. [Updated 2020 Mar 28]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK556475/

Juniper berries (Juniperus communis)
Raina R, Verma PK, Peshin R, Kour H. Potential of Juniperus communis L as a nutraceutical in human and veterinary medicine. Heliyon. 2019 Aug 31;5(8):e02376. doi: 10.1016/j.heliyon.2019.e02376. PMID: 31508527; PMCID: PMC6726717.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726717/

Vitamin C
Antioxidant therapy in idiopathic tinnitus “Patients underwent an 18-week oral treatment with a mix of phospholipids and vitamins (glycerophosphorylcholine, glycerophosphorylethanolamine, beta-carotene, vitamin C, vitamin E). ... Oral antioxidant therapy in patients with idiopathic tinnitus seems to reduce the subjective discomfort and tinnitus intensity and may be considered as an additional treatment modality.”
https://www.ncbi.nlm.nih.gov/pubmed/17416295